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Laura A. Solt, Ph.D., is an associate professor in the Department of Immunology and Microbiology at the Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology. She received her B.A. from Boston College, her Ph.D. in Immunology from the University of Pennsylvania, and was a postdoctoral fellow at the Scripps Research Institute’s Jupiter, Florida campus. She started her independent laboratory at Scripps Florida in 2013 to gain further insight into the transcriptional regulation of nuclear receptors and their ligand(s) to better understand signaling pathways that govern TH17 cell homeostasis vs. pathogenicity. Her lab also works in close collaboration with medicinal chemists to design and develop small molecule ligands to nuclear receptors to further probe their functions and evaluate their therapeutic potential. Using these approaches, her lab has described roles for RORα and the REV-ERBs in TH17 cell development and developed synthetic ligands to these receptors to target TH17-mediated chronic inflammation and autoimmunity.
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