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Improved Large Scale Production of Adeno-Associated Viruses Enables a More Efficient and More Potent Production of AAV VectorsThis production of highly concentrated and potent Adeno-Associated Virus (AAV) vectors has significant advantage over available protocol and allows for large-scale manufacturing of the virus. More than 6 percent of all gene therapy clinical trials worldwide use AAV vectors due to their... Published: 6/27/2021   |   Inventor(s): Barry Byrne, Nathalie Clement, Laura Adamson Keywords(s): AAV, Gene Therapy, HEK293, HSV Category(s): Technology Classifications > Human Health Care > Gene Therapy

AAV Gene Therapy for Complications with Diabetes and Vascular Diseases AAV Vectors Rely on Tissue-Specific Promoters to Target Vascular Endothelial Cells This AAV gene therapy transduces vascular endothelial cells and targets complications associated with diabetes and other vascular diseases. Available gene therapy vectors do not efficiently or selectively transduce vascular endothelial cells, which are associated with... Published: 6/27/2021   |   Inventor(s): William Hauswirth, Sanford Boye, Michael Boulton, Shannon Boye, Daniel Lipinski Keywords(s): AAV, Diabetes, Gene Therapy, hypercholesterolemia, Hypertension, retinal disease, vascular endothelial junctions, Vascular Repair Category(s): Technology Classifications > Human Health Care > Gene Therapy, Technology Classifications > Human Health Care > Therapeutics