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More Stable and Potent Galectin-1 Homodimer for Therapeutic Use in Inflammatory Diseases
Potently Modulates the Immune Response in Autoimmune and Chronic Inflammatory Disease Conditions
This polymer crosslinked, more stable Galectin-1 homodimer suppresses inflammation more potently than unmodified recombinant Galectin-1. Galectin-1 (Gal1) modulates innate and adaptive immunity by regulating dendritic cell migration, inducing activated...
Published: 7/22/2021
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Inventor(s):
Keywords(s): galectin, immune modulation, Immunotherapy, Inflammation Reduction, Lymphocytes, Oxydation, Pegylation, Protein Therapy
Category(s): Technology Classifications > Engineering > Materials, Technology Classifications > Human Health Care > Drug Delivery, Technology Classifications > Human Health Care > Therapeutics
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Therapeutic Nanoparticles for Non-Viral Drug Delivery to Natural Killer Cells
Transfects Natural Killer Cells Without the Use of VirusesThese nanoparticles enable the delivery of nucleic acids or drugs to immunosuppressed natural killer (NK) cells to restore their cytotoxic functions in tumor microenvironments. Globally, cancer causes one of every six deaths, with the number of new cases expected to rise to 23.6 million per year...
Published: 6/27/2021
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Inventor(s): Blanka Sharma, Isaac Adjei
Keywords(s): Drug Delivery, Immunotherapy, MNO2, Nanoparticle, Natural Killer Cells, nucleic acid delivery
Category(s): Technology Classifications > Engineering > Materials, Technology Classifications > Human Health Care > Drug Delivery
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Nanoparticle RNA Vaccine That Targets Slow-Cycling, Treatment-Resistant Cancer
Activates T-Cell Recognition of Tumor-Initiating Stem Cells in Mouse Model of Glioma This nanoparticle vaccine targets the slow-cycling, treatment-resistant, cancer stem cells to improve efficiency of anti-cancer drugs, thereby improving disease prognosis. Despite major developments in the field of anti-cancer therapies, tumor recurrence and metastasis...
Published: 2/13/2024
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Inventor(s): Elias Sayour, Loic Deleyrolle, Hector Mendez-Gomez, Sadeem Qdaisat, Duane Mitchell
Keywords(s): Cancer, cancer stem cells, Immunotherapy, Nanoparticles, Vaccine development
Category(s): Technology Classifications > Human Health Care > Therapeutics
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Loaded Dendritic Cells that Enhance Cellular Immunotherapy for Cancer
Increase Migration and Immune Response with Sarcosine-Loaded Dendritic CellsThese sarcosine-loaded dendritic cells exhibit enhanced migration to local lymph nodes, increasing the stimulation and migration of T-cells for cancer treatment. Immunotherapy has become a popular approach to treat cancer in recent years. A particular approach is providing patients...
Published: 6/27/2021
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Inventor(s): Maryam Rahman, Hassan Azari, Duane Mitchell, Rolando Lovaton
Keywords(s): adoptive cellular therapy, cellular trafficking, chimeric antigen receptor, dendritic cell, Immunotherapy, Immunotherapy of Cancer, Migration, n-methyl-glycine, sarcosine
Category(s): Technology Classifications > Human Health Care > Therapeutics
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