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Nanoparticle RNA Vaccine That Targets Slow-Cycling, Treatment-Resistant Cancer
Activates T-Cell Recognition of Tumor-Initiating Stem Cells in Mouse Model of Glioma This nanoparticle vaccine targets the slow-cycling, treatment-resistant, cancer stem cells to improve efficiency of anti-cancer drugs, thereby improving disease prognosis. Despite major developments in the field of anti-cancer therapies, tumor recurrence and metastasis...
Published: 2/13/2024
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Inventor(s): Elias Sayour, Loic Deleyrolle, Hector Mendez-Gomez, Sadeem Qdaisat, Duane Mitchell
Keywords(s): Cancer, cancer stem cells, Immunotherapy, Nanoparticles, Vaccine development
Category(s): Technology Classifications > Human Health Care > Therapeutics
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Chimeric Antigen Receptors T-Cell Therapeutics for Better Cancer Therapy
Specific Cytoplasmic Domains Increase Safety, the Signal Specificity and the Killing Efficacy of CAR T-CellsThese chimeric antigen receptors (CARs) include cytoplasmic domains that allow for targeting of specific cells, including autoimmune and cancer cells. Chimeric antigen receptors have the ability to graft onto immune effector cells such as T-cells...
Published: 6/27/2021
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Inventor(s): Lung-Ji Chang, Jan Moreb
Keywords(s): Antibody, blood cancer, Cancer, dendritic cell, Mulitiple myeloma, T cell, T regulatory cell, Vaccine
Category(s): Technology Classifications > Human Health Care > Therapeutics
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Compounds for Treating Cancer and Cancer Stem Cells
High-Throughput Assay and Compounds Selective for Targeting Refractory Cancers and Cancer Stem CellsCurrently, there are limited therapies available to treat people with refractory cancers like acute myeloid leukemia (AML), non-small cell lung cancer (NSCLC) and triple negative breast cancer (TNBC). To solve this problem, University of Florida scientists...
Published: 11/15/2021
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Inventor(s): Peter Sayeski, Amy Meacham, Christopher Cogle
Keywords(s): AML, Blood Vessels, Cancer, In vitro, leukemia, LLS, TPIMS
Category(s): Technology Classifications > Human Health Care > Therapeutics
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Two-Target Treatment that Inhibits Cancer Growth
Targets Thymidylate Synthase and Oncogenic Ras Signaling in Ras Mutant TumorsThis combination strategy contains inhibitors and pharmaceutically acceptable excipients for the treatment of various forms of cancer, such as breast cancer, prostate cancer, brain cancer, or pancreatic cancer. Cancer is the second leading cause of death in the United States....
Published: 6/27/2021
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Inventor(s): Maria Zajac-Kaye, Rony Francois
Keywords(s): Cancer, Drug combination, KRAS, RAS effectors, Thymidylate synthase
Category(s): Technology Classifications > Human Health Care > Therapeutics
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Gene Therapy for Reducing Lung Cancer Progression
Reduces Cancer Cell Growth and Survival by Targeting and Inhibiting lncRNAsThis gene targeting approach can reduce the progression of lung cancer that contains inactive signaling of the tumor suppressor gene LKB1 [Liver Kinase B1, also known as Serine/Threonine Kinase 11 (STK11)]. Lung cancer is the leading cause of cancer deaths in both men and women...
Published: 6/27/2021
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Inventor(s): Lizi Wu, Zirong Chen
Keywords(s): Cancer, Diagnostic biomarker, long noncoding RNA, Lung Cancer, Therapeutics
Category(s): Technology Classifications > Human Health Care > Diagnostics
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Anticancer Compound that Is More Effective and Less Toxic than Available Treatments
Thymidylate Synthase Inhibitor Employs Small Molecules to Inhibit Tumor Cell GrowthThese potential anticancer compounds offer an effective treatment that is less likely to cause resistance and recurrence of cancer and is less toxic to normal tissues than available chemotherapeutic agents. Thymidylate synthase inhibitors are a class of antineoplastic...
Published: 6/27/2021
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Inventor(s): Lidia Kulemina, Maria Zajac-Kaye
Keywords(s): Anti-Cancer Agents, Cancer, Chemotherapeutic Agents, Drug, inhibitors, Smal molecule, Thymidylate synthase
Category(s): Technology Classifications > Human Health Care > Therapeutics
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