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Chimeric Antigen Receptors T-Cell Therapeutics for Better Cancer Therapy
Specific Cytoplasmic Domains Increase Safety, the Signal Specificity and the Killing Efficacy of CAR T-CellsThese chimeric antigen receptors (CARs) include cytoplasmic domains that allow for targeting of specific cells, including autoimmune and cancer cells. Chimeric antigen receptors have the ability to graft onto immune effector cells such as T-cells...
Published: 6/27/2021
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Inventor(s): Lung-Ji Chang, Jan Moreb
Keywords(s): Antibody, blood cancer, Cancer, dendritic cell, Mulitiple myeloma, T cell, T regulatory cell, Vaccine
Category(s): Technology Classifications > Human Health Care > Therapeutics
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Panel of Monoclonal Antibodies for Characterization of AAV8 and AAV9 Capsids to Improve Therapeutic Efficacy of AAV Gene-Based Therapy
More Accurately Characterizes AAV8 and AAV9 Capsids for Development of Next Generation Vectors to Evade the Host's Immune Response This panel of antibodies allows better characterization of antigenic epitopes on AAV8 and AAV9 capsids with the goal of mitigating patient immune response to the existing AAV based gene therapy. Adeno-associated viral (AAV)...
Published: 6/27/2021
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Inventor(s): Mavis Agbandje-McKenna, Kim Van Vliet, Yu-Shan Tseng
Keywords(s): AAV Vectors, Antibody, Antibody-based assay, dot blot, Elisa, Hybridoma
Category(s): Technology Classifications > Research Tools > Biological Materials
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Antibodies and ELISA for Chondroitinase ABC
ELISA Determines ChABC Distribution and Content in Tissues and Bodily FluidsChondroitinase ABC (ChABC) is a bacterial enzyme that degrades sugar chains attached to the core protein of chondroitin sulfate proteoglycans (CSPGs). CSPGs are involved in a variety of biological processes in higher organisms, including humans. ChABC has a well-known potential...
Published: 7/12/2022
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Inventor(s): David Muir
Keywords(s): Antibody, Chondroitinase, Hybridoma, Immunochemistry, Monoclonal, Monoclonal Antibody, Research
Category(s): Technology Classifications > Research Tools > Biological Materials, Technology Classifications > Research Tools > Others
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Monoclonal Antibody against Connective Tissue Growth Factor
Belongs to the CTGF/Cyr61/Cef10/NOVH Protein FamilyConnective Tissue Growth Factor (CTGF) belongs to the CCN (CTGF/Cyr61/Cef10/NOVH) protein family, which is comprised of six secreted proteins that reside in the extracellular matrix (ECM). CTGF (Connective Tissue Growth factor) is a cysteine-rich, matrix-associated, heparin-binding protein. In vitro,...
Published: 6/27/2021
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Inventor(s): Gregory Schultz, Daniel Gibson, John Azeke, Priscilla Phillips, Edith Sampson, Paulette Robinson
Keywords(s): Antibody, CTGF, Elisa, Immunochemistry, Monoclonal, reagent
Category(s): Technology Classifications > Research Tools > Antibodies, Technology Classifications > Research Tools > Biological Materials, Technology Classifications > Research Tools > Others
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Monoclonal Antibody against Trinucleotide TNGW1 (TNRC6G)
RNA Interference with GW182 Results in Translation SuppressionRNA interference (RNAi), triggered by small interfering RNA and microRNA (miRNA), is a potent mechanism in post-transcriptional regulation for gene expression. GW182 is a 182kDa protein which binds to the 3’ untranslated region of mRNA targeted by miRNA and resulting in translation...
Published: 2/22/2024
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Inventor(s): Edward Chan, Songqing Li
Keywords(s): Antibody, GW182, Human, Monoclonal, reagent, RNA Interence, Translational Repression
Category(s): Technology Classifications > Research Tools > Antibodies, Technology Classifications > Research Tools > Biological Materials, Technology Classifications > Research Tools > Others
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A Monoclonal Antibody that Specifically Recognizes RAX/PACT Protein
Targeting a Protein that Initiates the Physiological Stress Response
Scientists at the University of Florida have developed a wide variety of monoclonal and polyclonal antibodies, cell lines, vectors and biological materials that can be used in other research projects. Anyone interested in accessing these materials via a license from the University...
Published: 7/12/2022
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Inventor(s): Richard Bennett, William May
Keywords(s): Antibody, Apoptosis, Monoclonal, Monoclonals, Mouse, PACT, RAX, Tumor
Category(s): Technology Classifications > Research Tools > Biological Materials, Technology Classifications > Research Tools > Others
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Monoclonal Antibody against Phosphorylated RAX/PACT Protein
Peptide Compose of RAX Amino Acides Used as Antigen to AntibodyMurine RAX (PKR Activator X) protein and its human ortholog PACT (Protein Activator of Interferon-induced Protein Kinase) are the only known cellular activators of the interferon-induced dsRNA-dependent protein kinase, PKR. RAX and PACT are 98% identical in amino acid sequence. In addition,...
Published: 7/12/2022
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Inventor(s): Richard Bennett, William May
Keywords(s): Antibody, Apoptosis, Monoclonal, Monoclonals, Mouse, PACT, RAX, Tumor
Category(s): Technology Classifications > Research Tools > Antibodies, Technology Classifications > Research Tools > Biological Materials, Technology Classifications > Research Tools > Others
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Monoclonal antibodies targeting enzyme involved in silencing mRNA, proteins associated with liver cancer, tumor growth and post-transcription gene silencing
Monoclonal Antibody against p62/IGF2BP2p62/IGF2BP2 is a cytoplasmic mRNA binding protein which binds to mRNA encoding IGF-II and may be involved in hepatic carcinogenesis because autoantibodies are found in a large percentage of patients with hepatocellular carcinoma. MAb were generated using the full length recombinant human protein as antigen. Monoclonal...
Published: 7/12/2022
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Inventor(s): Edward Chan
Keywords(s): Antibody, Human, Monoclonals, RNA, Tumor
Category(s): Technology Classifications > Research Tools > Antibodies, Technology Classifications > Research Tools > Biological Materials, Technology Classifications > Research Tools > Others
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Monoclonal Antibody against CUGBP2/ETR-3 Proteins
Recognizes Both Human and Mouse CUGBP2/ETR-3 Proteins but Does Not Bind to Other CELF Family MembersCUGBP2/ETR-3 is a member of the CELF family of pre-mRNA alternative splicing factors which play an important role in the appearance of specific protein isoforms during postnatal development. The CELF family has also been implicated in the neuromuscular...
Published: 7/12/2022
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Inventor(s): Maurice Swanson
Keywords(s): Antibody, COX2, CUGBP2, Monoclonals, Myotonic Dystrophy, RNA Splicing, RNA Turnover
Category(s): Technology Classifications > Research Tools > Antibodies, Technology Classifications > Research Tools > Biological Materials, Technology Classifications > Research Tools > Others
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Monoclonal Antibody Against Cholecystokinin (CCK) Receptor 2
Targeting Proteins that Regulate Anxiety and Digestion
Scientists at the University of Florida have developed a wide variety of monoclonal and polyclonal antibodies, cell lines, vectors and biological materials that can be used in other research projects. Anyone interested in accessing these materials via a license from the University of Florida should...
Published: 7/12/2022
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Inventor(s): Martha Campbell Thompson
Keywords(s): Antibody, CCK, CCK2, CCKB, Gastrin Receptor, Monoclonals
Category(s): Technology Classifications > Research Tools > Biological Materials, Technology Classifications > Research Tools > Others
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