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Adeno-Associated Virus-Based Serpin Delivery for Use as Anti-Inflammatory Gene Therapy
Recombinant Adeno-Associated Virus (rAAV) Vector Expressing Serine Proteinase Inhibitor 1 for Inhibiting Multiple Targets in the Inflammatory Cascade
This recombinant AAV vector encoding a serine proteinase inhibitor (Serp-1) downregulates inflammation by targeting and inhibiting human serine proteinase enzymes. Inflammatory disorders, including lupus,...
Published: 3/28/2025
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Inventor(s): Alfred Lewin, Alexandra Lucas, Westley Reeves, Douglas McFadden, Cristhian Ildefonso, Sriram Ambadapadi
Keywords(s):
Category(s): Technology Classifications, Technology Classifications > Human Health Care, Technology Classifications > Human Health Care > Gene Therapy, Technology Classifications > Human Health Care > Therapeutics
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Tiancimycins for Effective Cancer Treatment
Serve as Highly Cytotoxic Payloads in Site-Specific Anticancer Antibody-Drug Conjugates
Tiancimycins are a newly discovered class of enediynes that are ideal payload candidates for anticancer antibody-drug conjugates (ADCs). The substantial toxicity of enediynes limits their use as anticancer drugs unless they can be precisely directed to tumor cells....
Published: 2/22/2024
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Inventor(s): Ben Shen
Keywords(s):
Category(s): Technology Classifications, Technology Classifications > Human Health Care, Technology Classifications > Human Health Care > Therapeutics, Technology Classifications > Human Health Care > Drug Delivery
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Dissociated Glucocorticoids for Improved Inflammation Treatment
Reduces the Side Effects of Glucocorticoid Drugs, Preventing Skeletal Muscle Wasting
These potent anti-inflammatory compounds have been designed to treat inflammatory conditions but with reduced, serious side effects associated with the long-term use of traditional glucocorticoid drugs. Glucocorticoids are one of the most prescribed drug classes due...
Published: 2/20/2024
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Inventor(s): Kendall Nettles, Theodore Kamenecka, Nelson Bruno, Glenn Micalizio
Keywords(s):
Category(s): Technology Classifications, Technology Classifications > Human Health Care > Therapeutics, Technology Classifications > Veterinary > Therapeutics
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Dynamic Obfuscation Technique for Firmware Protection of Internet-Embedded Systems
Enhances the Security of Internet-of-Things Devices Against Firmware Attacks
This obfuscation technique enhances the firmware security of internet-embedded systems in security-critical applications. The number of embedded systems is increasing exponentially globally with the advent of technology and the ever-growing demands for automation. However,...
Published: 5/1/2023
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Inventor(s): Mark Tehranipoor, Farimah Farahmandi, Fahim Rahman, Muhammad Monir Hossain
Keywords(s):
Category(s): Technology Classifications > Engineering > Electrical, Technology Classifications, Technology Classifications > Others > Security
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Light Magnesium-Lithium Alloys for Automotive, Space, and, Aviation Applications
Magnesium-Based Alloys that Are Tougher, Stronger, and Lighter than Conventional Materials
These magnesium alloys are designed for use where lightweight and high-strength are crucial, such as in airplanes, automobiles, and space craft. Magnesium alloys have a wide range of applications because they have a low density and have high specific strength...
Published: 3/13/2023
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Inventor(s): Michele Manuel, David Christianson
Keywords(s):
Category(s): Technology Classifications, Technology Classifications > Engineering > Materials
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Waste Treatment for Separating PFAS from Landfill Leachate
Isolates Perfluoroalkyl Substances from Leachate into a Concentrated Stream for Proper Destruction
This waste treatment system removes per-fluorinated compounds from landfill leachate before they can enter the ground water. Landfill leachate is the liquid that forms when rainwater percolates through landfills and collects toxic substances. Compounds...
Published: 10/5/2021
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Inventor(s): Timothy Townsend, John Bowden, Michael Annable, Nicole Robey
Keywords(s):
Category(s): Technology Classifications, Technology Classifications > Environmental > Solid, Technology Classifications > Engineering > Others
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