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Metabolically Stable Sigma Receptor and Opioid Receptor Modulators for Treating Addiction
Dual-Action Small Molecules Target Withdrawal and Craving to Combat Opioid Use Disorder
These sigma receptors and opioid receptor modulators present improved metabolic stability and bioavailability for treating opioid addiction. While opioid preparations such as morphine have been mainstays for pain management since the early 1800s, overprescribing...
Published: 3/26/2026
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Inventor(s): Christopher McCurdy, Hebaalla Agha, Sebastiano Intagliata, Morgan Crowley, Sushobhan Mukhopadhyay, Sampa Gupta, Sarah Burns
Keywords(s):
Category(s): Technology Classifications > Human Health Care > Therapeutics
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Polymerase-Theta Inhibition for Treating Epstein-Barr Virus (EBV) Cancers and Related Diseases
Proteolysis Targeting Chimeras (PROTACs) Block Microhomology or Theta-Mediated End Joining in Cancer Cells
These polymerase theta inhibitors treat Epstein-Barr virus (EBV)-associated cancers and related diseases. EBV cancers are linked to two percent of the global cancer burden and are difficult to treat, demonstrating a strong need for effective...
Published: 3/18/2026
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Inventor(s): Sumita Bhaduri-McIntosh, Michael McIntosh, Guangrong Zheng, Hui Chen
Keywords(s):
Category(s): Technology Classifications > Human Health Care > Therapeutics
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Anodization Tool for Uniform Titanium Oxide Nanotubes on Non-Conductive Surfaces, Enabling Advanced Dental Implants and Biomedical Devices
Produces Titanium Oxide Nanotubes, Enhancing Dental Implants with Antibacterial and Biocompatible Properties
Dental implants and other load-bearing biomedical devices rely heavily on surface properties to achieve long-term stability, osseointegration, and resistance to bacterial colonization. These are important aspects of modern dentistry that impact...
Published: 3/20/2026
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Inventor(s): Josephine Esquivel-Upshaw, Fan Ren, Chao-Ching Chiang
Keywords(s):
Category(s): Technology Classifications > Human Health Care > Therapeutics
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Combination Genetic Engineered Cell Therapy for Targeted Immune Protection of Stem Cell-Derived Beta Cells
Localized Immune Tolerance for Safer and Effective Type 1 Diabetes Therapy
This engineered cell therapy combination was developed to treat Type 1 diabetes. Type 1 diabetes (T1D) is a chronic autoimmune disease caused by an autoimmune attack on the insulin-producing pancreatic beta cells. It affects approximately 8.4 million people worldwide, with prevalence...
Published: 3/10/2026
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Inventor(s): Holger Russ, Leonardo Ferreira
Keywords(s):
Category(s): Technology Classifications, Technology Classifications > Human Health Care > Therapeutics
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Small-Molecule IL-6 Inhibitors Targeting gp130 for Anti-Cancer Therapy
Blocks IL-6-gp130 Signaling for Cost-Effective Treatment of Autoimmune Diseases and IL-6–Driven Cancers
These small-molecule interleukin-6 (IL-6) inhibitors target glycoprotein 130 (gp130) by blocking IL-6-gp130 signaling, delivering a cost-effective therapy for autoimmune diseases and IL-6-driven cancers. IL-6-gp130 signaling drives tumor growth...
Published: 3/31/2026
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Inventor(s): Chenglong Li, Liguang Mao, Daniel Schultz, Zhihang Shen, Xiaozhi Yang, Wei Zhou
Keywords(s):
Category(s): Technology Classifications > Human Health Care > Therapeutics
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Negative Autoregulation for Safe Cas13-Based RNA Therapeutics
Mitigates Collateral RNA Damage in Repeat Expansion Disorders
These negative autoregulatory approaches enable safe Cas13-based RNA therapeutics for mitigating collateral RNA damage when treating repeat expansion disorders. CRISPR-Cas13d is an enzyme in the CRISPR family of genome editing tools. Cas13d has been shown to have immense therapeutic potential...
Published: 3/18/2026
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Inventor(s): Eric Wang, Chase Kelley
Keywords(s):
Category(s): Technology Classifications > Human Health Care > Therapeutics, Technology Classifications > Research Tools > Therapeutics
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Potent Chemotherapeutic Compound for Treatment of Brain Cancer
Amphiphilic Fatty Acid Ether Compounds for Targeting Cancerous Cells of the Central Nervous System
Analogs of isopropyl aminopropanol (AIP) have been linked to the beta-adrenergic receptor polar head to generate chimeric molecules with potent antitumor properties. These novel compounds readily penetrate the blood-brain barrier and have been shown to...
Published: 2/17/2026
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Inventor(s): Stanislav Svetlov
Keywords(s):
Category(s): Technology Classifications > Human Health Care > Therapeutics, Technology Classifications > Agricultural > Therapeutics
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Bacterial Extracellular Vesicles for Treating Viral Infections
Uses Lactobacillus-Derived Extracellular Vesicles as Natural Antiviral Agents
These Lactobacillus-derived extracellular vesicles (EVs) activate antiviral pathways and modulate host immunity to treat avian flu. Bacterial extracellular vesicles are increasingly at the forefront of research as mediators of host-microbe interactions. EVs are ubiquitously...
Published: 3/18/2026
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Inventor(s): Graciela Lorca, Claudio Gonzalez
Keywords(s):
Category(s): Technology Classifications > Research Tools > Therapeutics, Technology Classifications > Human Health Care > Therapeutics
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Oncolytic Dual Targeting Agent for Treating Diseases Associated with the Epstein-Barr Virus (EBV)
Identifies and Eliminates Specific Enzymes that Cause Cell Growth in EBV-Associated Cancers
This dual targeting agent reactivates the Epstein-Barr virus (EBV) to treat cancer patients by targeting enzymes that support the EBV latent state and thereby, uncontrolled EBV-cancer cell growth. The Epstein-Barr virus is a human herpesvirus infecting most...
Published: 2/12/2026
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Inventor(s): Sumita Bhaduri-McIntosh, Yufeng Xiao, Guangrong Zheng, Michael McIntosh, Beth Rousseau
Keywords(s):
Category(s): Technology Classifications > Human Health Care, Technology Classifications > Human Health Care > Therapeutics
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Cancer Cell-Targeting Salmonella Strains for Cancer-Specific Treatment
Cancer-Targeting Engineered Bacteria Directly Attacks Tumors and Stimulates Immune Defenses
This cancer-targeting Salmonella platform delivers therapeutic proteins directly to cancer tissue, reducing the growth of a tumor or regressing it. Cancer ranks as the second most common cause of death in the United States. Bacteria have been used to target...
Published: 2/5/2026
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Inventor(s): Roy Curtiss, Shifeng Wang
Keywords(s):
Category(s): Technology Classifications > Human Health Care > Therapeutics
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